MicroRNA Expression of Primary and Metastatic Colorectal and Breast Carcinoma

Background: Colorectal and breast carcinoma are frequently diagnosed cancers. At advanced stages, cancers metastasize to certain organs resulting in loss of function these organs, eventually death. Therefore, there is a specific need for the prognosis Currently, microRNAs (miRNAs), have emerged as new target cancer-specific biomarker. Objective: To examine expression miRNA primary metastatic colorectal Methods: This study investigated 6 miRNAs (miR-10b, miR-21, miR-145, miR-155, miR-200c, miR-373) formalin fixed paraffin embed tissues from pairs normal with tumor samples cases Ramathibodi Hospital, Thailand by real-time RT-PCR. Results: Among miRNAs, miR-145 decreased significantly all carcinoma. There was compared their (P < .05). Whereas miR-10b, miR-200c showed expression; miR-373 an increased majority cases. Unlike other no significant difference > Conclusions: finding indicates that may be potential Decrease could applied therapy